Rsid snp

1 coordinates. It stands for . Columns two and three contain the chromosome and basepair positionI have a simple question about the dbSNP build used for rsid number in DGN_WB the rsid numbers are this will help me correct some SNP's labels and UKBB GWAS Manifest 20170915 Share. Email The SNP Consortium is a nonprofit organization that sequences and records single nucleotide polymorphism records in a public domain Genome Graphs User's Guide Contents Genome Graphs is a tool for displaying genome-wide data sets such as the results of genome-wide SNP dbSNP rsID: e. The more common Gene/Protein Consequences (maximum 3 at a time), RefSeq. If your question is related, just write that as a comment, or a new question if needed. dbSNP. CADD - Combined Annotation Dependent Depletion fitCons - Fitness Consequences of Functional Annotation EIGEN - Unsupervised Spectral Aprroach Integrating Functional Annotation I looked up the SNP associated with my COL5A1 mutation (found with GeneDx clinical testing) in 23 and me and that SNP was not reported. CADD - Combined Annotation Dependent Depletion fitCons - Fitness Consequences of Functional Annotation EIGEN - Unsupervised Spectral Aprroach Integrating Functional Annotation Column one provides the SNP identifier (rsID where possible). After the add operation I checked the gsr. The tables in the database can be grouped into four categories: tables in which the data has been split into a separate table for each chromosome The following list of Y-STR markers are commonly used in forensic and genealogical DNA testing. Note: if the profile belongs to a female, the paternal (y) haplogroup and terminal SNP information will be null . RSID stands for Reference SNP identificationrs1800562 represents a SNP that accounts for ~85% of all cases of hemochromatosis, a disorder whose symptoms include cirrhosis of the liver, diabetes, hypermelanotic 23-11-2018 · The results files contain the following four data columns: RSID – The RSID column provides the RS number for the SNP in the NIH dbSNP database. Returns const_iterator to the beginning of the allele vector, for iteration SNPTEST is a program for the analysis of single SNP association in genome-wide studies. Maternal terminal SNPs include the rsid and rCRS reference position, while the paternal ones include the rsid and ISOGG SNP. Hsapiens. MASA is closely related to the concept of multiple testing. table Name of the SQLite table to be created. If the allele is (C) and the same chromosome also harbors the rs7412(C) allele, the combination is known as an APOE-ε4 allele. The RSID is followed by the chromosome number and the position in base pairs on the forward strand that the SNP is located on the chromosome. Locatie: 8600 Rockville Pike, Bethesda, MDdbSNP - WikipediaDeze pagina vertalenhttps://en. A variety of queries can be used for searching: an ss number ID, a refSNP number ID, a gene name, Please, do not ask questions in the answers section. SNP rsID Minor Allele Functional Summary-based Imputation. eQTL Community Analysis Legend QTL Associations. udacity. This is a cis-eQTL database of microdissected healthy human kidney glomeruli and tubuli of subjects of European descent. - MAF: SNP minimum allele frequency (in HapMap CEU) - Allele: the considered allele (+strand) - TargetSite: the 8 nucleotides of the mRNA at the seed site and the seed type for the given allele. ALLERGY Gene rsID Genotype Phenotype HLA rs2155219 GG +/+ HLA Click on the links in the Gene column to learn more about each SNP. BCFtools is a set of utilities that manipulate variant calls in the Variant Call Format (VCF) and its binary counterpart BCF. It is a plain text tab-separated file with each line annotating single protein variant (amino acid residue substitution). The rs number is an accession number used by researchers and databases to refer to specific SNPs. 87179601A>G Gly412 rs1128503 Hertz, 2016 g. CADD - Combined Annotation Dependent Depletion fitCons - Fitness Consequences of Functional Annotation EIGEN - Unsupervised Spectral Aprroach Integrating Functional Annotation A Single nucleotide polymorphism or SNP (pronounced snip) is a DNA sequence variation occurring when a single nucleotide - A, T, C, or G - in the genome (or other shared sequence) differs between members of a species (or between paired chromosomes in an individual). SNP Info file: SNP Info file, which is discussed below SNP Info file contains information about each SNP on each line, and there are three columns. chr: chromosome of top lead SNP; pos: position of top lead SNP on hg19; P-value: P-value of top lead SNP Identification of SNP and gene map positions from an updated reference genome > dim(snpMapAnn$rsid_map) [1] 306252 3 > dim(snpMapAnn38$rsid_map)bigsnpr {bignspr} is an R package for the analysis of massive SNP arrays. For now, this package only read bed/bim/fam files (PLINK preferred format) using snp_readBed. *Note: multiple listings of SNP rsid are allowed. Cell Line Models for Genome Wide Association Mapping in Cancer Drug Response or downstream of the SNP, respectively. 23andme provides 610545 RSID records (SNP, Chromosome, Position, Genotype). 92%. Sign in. All of 23andMe SNPs are oriented towards the positive (“plus”) strand, based on the GRCh37 reference human genome assembly build. Initial studies showed that the risk ‘T’ allele was associated with increased CBS activity 7 , although later studies showed no risk, or even the opposite effect 8 , 9 . GG = no SNP of MTHFR C677T (-/-) Compound Heterozygous A1298C=GT + C677T=AG is referred to as “Compound Heterozygous” meaning one has a single copy of each mutation. g. DATASET VARIABLE DESCRIPTION DATA TYPE VALUE CODES SNP rs6311 NCBI rsID character N/A SNP rs9534512 NCBI rsID character N/A SNP rs1923882 NCBI rsID character N/A On the ISOGG page, each SNP entry will have something in the rightmost column like "A->T" or "G->A". a. com alerting me that my genetic profile was ready. A SNP is a location in the genome that is known to vary between individuals. The Segment size indicates the length of the matching segment between two people, measured in centiMorgans (cM). In order to help users easily obtain rs numbers for SNPs of interest, we have provided a mapping file called “HRS_1000G_rsid_map. Identification of SNP and gene map positions from an updated reference genome Many GWAS of SNP associations were based on an old reference genome build, e. SNP's of genetically inherited traits, conditions and diseases If you tested your DNA with a personal genomics service like 23andMe , DeCODEme , FTDNA 's Family Finder or another testing company, you can learn more about your risk factors for hundreds of diseases. Get the definition of RSID by All Acronyms dictionary. dbSNP rsID Q: is it OK to describe a variant using its dbSNP ID, like rs1234567:T>C? A: yes, a variant may be described using its dbSNP ID, like rs1234567:T>C. Risk alleles : Substantially lower risk (over 3x less), moderately lower risk (up to 3x less), normal, slightly 10-2-2014 · STRs vs SNPs, Multiple DNA Personalities. Please note that only positions of build 37 are supported. Single nucleotide polymorphisms, frequently called SNPs (pronounced “snips”), are the most common type of genetic variation among people. RSID stands for Reference SNP identificationlivewello Gene Variance report Annabel 6 / F ALLERGY Gene rsID Minor Allele Genotype Phenotype 1 HLA rs2155219 G GG +/+ 2 HLA rs7775228 C CT +/-A gene variance report For things like germline polymorphisms, it would be good to have a field to put the rsID. When a person’s DNA is analyzed, like 23andme does, instead of just listing out your entire DNA, they match your nucleotides to those listed in the database, and the result is a long list of those. Columns two and three contain the chromosome and basepair position rsid chromosome Thus, at a minimum, I would like the output to include the SNP rsID and the SNP chromosomal location of my index dataset as well as the corresponding gene with it's chromosome, gene start and gene end locations. SnpData. Jun 8, 2018 This SNP, located in the fourth exon of the ApoE gene, affects the amino acid at position 130 of the resulting protein. SNP rsID as provided by UK Biobank: 18. RSID SNP: 16: 10093947: 10000090: rs1016063312: C: A,T: NIH DBSNP VCF b151 GRCh38p7: Position hg18: 10001448: RSID SNP: 16: 10093948 G6PD GENE. Hi, Thank you. BRCA1 is a human tumor suppressor gene. com/course/bio110. Note that for SNPs with rsID, the rsID should be specified as their SNP names. csv), loci name to rsID conversion file the SNP list for the SNPinfo is designed to comprehensively utilize computational (function prediction of SNP allele), experimental and epidemiological information together with recent 23-2-2015 · This video is part of an online course, Tales from the Genome. Effect of Non-synonymous Coding SNPs on Protein Function, SIFTUsers can annotate a single SNP, insertion/deletion (InDel) or block substitution by selecting one of the input formats and supplying the required data into the 11 Dec 2017 sets of SNPs relevant to specific genes, so we refer to them as Gene similar SNP Table is made which contains rsIDs, chromosomes, and. txt. com/course/bio110. e. 20111119 library The Bovine Genome Database is supported by the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no. Each SNP represents a difference in a single DNA building block, called a nucleotide. The e4 version of the APOE gene increases an individual's risk for developing late-onset Alzheimer disease. The first column is the rsID for the SNPs. rsid snp k. HLA-DRB1 and HLA-DQB1. However, SNP genotyping technology is rapidly progressing with the emergence of novel, faster and cheaper methods as well as improvements in the existing methods. It enhances the features of package {bigstatsr} "rs4970420") snp_gene (rsid) Large-scale testing for SNP-motif interactions. Bettinger, Ph. CHR - SNP location in GRCh37. rs66823261) to IGV to then be able to jump to the location of each of them when copy+pasting the rsID on the The resulting many-megabyte file is full of rsid data and the actual For each trait I cross-referenced the SNP database with 23andMe data to make sure the API Reference (deprecated) Maternal terminal SNPs include the rsid and rCRS reference position, while the paternal ones include the rsid and ISOGG SNP. A SNP is a location in the SNP RSID PARENT GENE & VARIANT ⚛ CATEGORY ☤ / PATHWAY ⥹ rs1801272 CYP2A6*2 A1799T Chemoprotection / Detox I rs6583954 CYP2C19 Chemoprotection / Detox I23andme provides 610545 RSID records (SNP, Chromosome, Position, Genotype). MASA is a new association testing method incorporating prior information to increase power. I compared mine to a person who is not related to me in any way and about 42% of the 20-11-2018 · Single nucleotide polymorphisms, frequently called SNPs (pronounced “snips”), are the most common type of genetic variation among people. Make sure the FILE contains a proper header line so that R will recognize the columns (for example, look at the DGI_chr9_hit. Genome Graphs User's Guide Contents Genome Graphs is a tool for displaying genome-wide data sets such as the results of genome-wide SNP dbSNP rsID: e. The query pages takes ~30sec to load, because of the large memory requirement for the genome-wide results. info:How to compare SNP from genotyping results for multiple people with a known phenotype? or is it a combination of rsid and position?What do rs id, allele coded 0 and allele coded 1 mean? up vote 3 down vote favorite. Thus there should not be any entry in the files that have the same rsid but different chromosomes and/or positions. Welcome to the Geography of Genetic Variants (GGV) browser! To begin, pick a dataset on the dropdown menu. One can search variants within a dataset by its rsID or position (Use the format chromosome where SNP refers to the central associated SNP (give the rsID), CHR refers to the chromosome it's on, and FILE is the name of the file containing the association data (like DGI_chr9_hit. rsID: rsID of the top lead SNP based on dbSNP build 146. nih. 23andMe to plink. Watch Sandbox demo video Is it possible to load a list of rsID identifiers (e. When researchers identify a SNP, they send a report (which includes the sequence immediately surrounding the SNP) to the dbSNP database. The reported total sample count for this SNP is probably incorrect. How should I interpret my raw DNA data? The name of the variant with its rsID (= Reference SNP cluster ID), Each SNP position can have a combination of two 23-11-2018 · The results files contain the following four data columns: RSID – The RSID column provides the RS number for the SNP in the NIH dbSNP database. A place to capture information about various SNP databases that exist. g Does anyone know of a way to convert single nucleotide polymorphism (SNP) IDs from rs# to SNP_A-#? I have two SNPs, rs429358 and rs4420638, and need to determine Fat mass and obesity-associated protein (FTO) is an enzyme which interacts with RNA molecules and is thought to influence expression of proteins, it is encoded for by Genotyping Glossary. Get a constantly updating feed of breaking news, fun stories, pics, memes, and videos just for you. Contribute to chandlerzuo/atSNP development by creating an account on GitHub. g Welcome to the Mutalyzer website. The Single Nucleotide Polymorphism Database (dbSNP) is a free public archive for genetic To accommodate this, dbSNP routinely assembles identical submitted SNP records into a single reference SNP record, which is also a unique and If you're comfortable with scientific literature and want to see equations to deal with SNP data, I might recommend having a look here:. I explain that an STR or Short Tandem Repeat is a different kind of a mutation than a SNP rsid position RSID SNP: 20: 9980760: 10000112: rs1013608274: G: A: NIH DBSNP VCF b151 GRCh38p7: Position hg18: 9928760: RSID SNP: 20: 9980765: 10000117 Does anyone know of a way to convert single nucleotide polymorphism (SNP) IDs from rs# to SNP_A-#? I have two SNPs, rs429358 and rs4420638, and need to determine . One common task that many users need to use ANNOVAR for is to assign dbSNP identifiers to variant calls in a VCF file. It stands for Reference SNP cluster ID and is the naming convention used for most SNPs. gz?) One of our current projects is a systems genetics project that involves the interrelation of multiple genetic datasets containing human genetic variants. The version of the browser you are using is no longer supported. Currently have 136 STR marker labels on Chromosome Y; Currently have 364,811 SNP marker labels on Chromosome Y 10 meanings of RSID acronym and RSID abbreviation. RSID – Provides the Reference SNP cluster (RS) number for the SNP in the NIH dbSNP database. but, you should also at least once give the description of the variant based on a genomic reference sequence. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone. But on 23andme I got R-M417. North Deerfield, IL, USAList of cancers with the associated genes and alleles. SNP RSID PARENT GENE & VARIANT ⚛ CATEGORY ☤ / PATHWAY ⥹ rs6088659 GSS A5997G Chemoprotection / Detox II rs1056806 GSTM1 Chemoprotection / Detox II Genotype '> >>> ~ snp. META reads plain text files at input, with each line of each file represeting the information of a SNP. Development and Evaluation of a Transfusion Medicine Genome Wide SNP Array Yuelong Guo1, Grier P Page2, Mark Seielstad3,4, Brendan Keating5, Connie M Westhoff6, Carolyn Hoppe7, Aarash Bordbar8, SNP = Variant RSID from dbSNP (given as “. SNP reported: Whether the known SNP is directly reported in the study. gov if you have any comments Nov 20, 2018 Single nucleotide polymorphisms, frequently called SNPs (pronounced “snips”), are the most common type of genetic variation among people. I have a simple question about the dbSNP build used for rsid number in DGN_WB and GTEx models. Each line # corresponds to a single SNP. k. /plink --bfile mydata --update-map rsID. 998). The default output including all SNPs (both SNPs without MAF and SNPs with MAF information). It stands for Reference SNP cluster ID. Drug Class Chrom. nlm. A Single Nucleotide Polymorphism (or SNP; often pronounced "Snip") is a specific nucleotide locus (or base-pair location) in a DNA strand that has exhibited a variation in some portion of the population. "AlleleFreqSumNot1" => 0, # Allele frequencies do not sum to 1. I would prefer using R to accomplish this goal. Often, there will be SNPs that contradict each other in the SNP analyzer. 20120608 package Hi, Has anyone ever had a case where a SNP was not found in SNPlocs. For each SNP, we provide its identifier # (an rsid or an internal id), its location on the reference human genome, and the # genotype call oriented with respect to the plus strand on the human reference # sequence. The rCRS (also called position) is a number more commonly used but specific to a gene or, in this case, the mtDNA. of a tag SNP approach stems from the inherent correlation among markers—the selection of one highly correlated marker serves as a proxy for a number of additional, highly correlated markers across the SNP rsID Hertz, 2016 g. Risk alleles : Substantially lower risk (over 3x less), moderately lower risk (up to 3x less), normal, slightly 31-8-2018 · I found quite a number of SNPs on a chromosome at a specific position, where a different RSID was used for that SNP. The more common Hi Deepak,. UKBB GWAS Manifest 20170915 Share. . com/a/2715Is it possible to load a list of rsID identifiers (e. g. The position of the SNP can change when the powers that be come out with a new “build” of the genome. I have results from AncestryDNA with ~ 668 943 SNPs. txt). The C allele is completely absent in the British, Danish, European American, Irish, and Orcadian Nordic populations. The rsID number is a unique label ("rs" followed by a number) used by researchers and databases to identify a specific SNP (Single Nucleotide Polymorphism). Following is a description of PolyPhen-2 annotation summary report. One of the questions I receive rather regularly is about the difference between STRs and SNPs. The Bovine Genome Database is supported by the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no. This is the change that indicates whether or not someone is positive for that particular haplogroup. METASOFT is a free, open-source meta-analysis software tool for genome-wide association study analysis, designed to perform a range of basic and advanced meta-analytic methods in an efficient manner. rs66823261) to IGV to then be able to jump to the location of each of them when copy+pasting the rsID on the locus text box? This is a cis-eQTL database of microdissected healthy human kidney glomeruli and tubuli of subjects of European descent. North Deerfield, IL, USASNPsnap - matching SNPs based on genetic properties. Using the remainder of SNPsnap - matching SNPs based on genetic properties. 20120608, but The problem of r function rsidsToGRanges in SNPlocs. The software provides SNP ID- and gene-centric online retrievals for SNP information and tag SNP selection from dbSNP/NCBI and HapMap, respectively. This is usually in the form of chr:position , but could be the rsid of the variant if the user had selected --rsid during the Minimac3 run (provided the input reference panel as the rsid in the INFO column). Avey founded 23andMe with Anne Wojcicki, wife of Google co-founder Sergey Brin For each SNP, we provide its identifier # (an rsid or an internal id), Reference SNP identification definition, categories, type and other relevant information provided by All Acronyms. It's also possible download the full list of genes affected. The SNP has potential clinical implications as determined by published research. SNP must have a rsID and map to a unique genomic location The "consensus" data set contains data for 1115 individuals (558 males, 557 females; 924 founders and 191 non-founders), only keeping SNPs that passed QC in all populations (overall call rate is 0. SNPs for which there are no LD proxies or no MAF data available are listed in the output file nonannoted. SnpItems count and got the expected non-zero value. Occasionally you will have a "No Call" where they were unable to declare what values were there. Product Name – The name of the GeneChip® probe array or Targeted Genotyping panel name where the given Probe Set or SNP is located. Enhance your SNP-based enrichment analysis. You will need to know which array they come from but it is probably the human Genomewide SNP 6. rsid chromosome position allele1 allele2 rs4477212 1 82154 T T Can you explain why there would be a difference if the build is the same and the snp is the same? Reddit gives you the best of the internet in one place. CHROMOSOME – The CHROMOSOME column provides the name of the chromosome where the SNP is located. genotype < Genotype 'TT' > The complement is important due to eah SNPs orientation. The Short Genetic Variations database (dbSNP) is a public-domain archive for a broad collection of comman and rare small germline and somatic sequence variations. Affymetrix microarray solutions include necessary components for a microarray experiment, from arrays and reagents to instruments and software, enabling scientists and clinicians to understand, identify, create, and improve genetic marker-assisted breeding programs in agriculture for human health and wellness. RSID – The RSID column provides the RS number for the SNP in the NIH dbSNP database. Auteur: UdacityWeergaven: 73Videoduur: 3 minsnp - IGV jump to rsID location - Bioinformatics …Deze pagina vertalenhttps://bioinformatics. Hi I am working on SNPs genotyping and I have made literature search and some non-redundant Reference SNP cluster, which is assigned a unique rsid. All commands work transparently with both VCFs and BCFs, both uncompressed and BGZF-compressed. SNPs represent the most frequent type of DNA variation found in the human population. When the track is viewed in the pack or full mode, the rsID is displayed right next to each known SNP while the SVM-model-based filtering status is displayed for each novel SNP from ESP project. Please, do not ask questions in the answers section. Although the format is quite flexible, following column names must be provided: Although the format is quite flexible, following column names must be provided: SNP_ID: rsid(s) of SNP(s) located in the probe. This SNP's allele frequency data are probably incomplete. mygenefood. NCBI36. Select the "SNP" radio button and upload a list of RSid in a text file . The two columns labeled “effect” show the change in odds for developing Type 2 Diabetes when either one or two copies of the less prevalent version of the SNP are present compared with the odds of developing the disease SNPTips™ is a Firefox browser extension that allows customers of the 23andMe personal genomics service to access their SNP genotype information without leaving the web page they're reading. SNPsnap accepts the below SNP list input format as text file or copy/paste into the browser: One SNP per line SNP identifers can consists of chromosomal coordinates, rs-numbers or a mixture of the two. 87179809C>T Ser400Asn rs2229109 Rossi, 2009 g. Also included are sites / tools to convert and lookup SNP s. rs. Info provides simple-to-use REST web services to query/retrieve genetic variant annotation data. Introduction ‘rsid_map’ contains all SNP identifiers that can be found for their genomic positions. You shouldn't use the information as factual, but rather as something to look more into. I mean, if you took the 0 allele at every SNP registered with a rsID, Data items should be in order: RSID, Chromosome Number, SNP Position Number, a single string with both alleles A space-separated file with no quotes on any data. Reference SNP cluster ID. SNPinfo is designed to comprehensively utilize computational (function prediction of SNP allele), experimental and epidemiological information together with recent genome wide association (GWAS) results and linkage disequilibrium (LD) information to prioritize SNPs for further genetic mapping studies SNP Single nucleotide polymorphisms, frequently called SNPs (pronounced 'snips'), are the most common type of genetic variation among people. My genetics November 11, 2013 178 comments Y esterday evening I ran up to my computer and started clicking madly in every direction after I saw an email from 23andme. Possible values: Y(yes), N(no) Associated SNPs: SNPs associated with the disease as reported Luckily, 1926013 of my 1936864 SNPs (99. DYS454 is the least diverse, and multi-copy marker DYS464 is the most diverse Y-STR marker. snp The SNP identifier for the variant. Columns four and five contain the two alleles observed at this SNP (genotype). Auteur: UdacityWeergaven: 73Videoduur: 3 minSLC2A14 gene - mutations and nutrition …Deze pagina vertalenhttps://www. 22-9-2013 · Users can simply hover their mouse cursor over a SNP RSID on a webpage and, if that was tested by 23andMe, – The Genetic Genealogist <Loved it!Genotyping Glossary. get const_iterator to the beginning of the allele vector, for iteration . a. id")Column Description; rsid: SNP ID: chrom: Chromosome of existing SNP: pos: Position of existing SNP: genotype: Genotype of existing SNP: chrom_added: Chromosome of 3D genome browser, Hi-C browser, ChIA-PET browser, Capture Hi-C browser. DNA: UNLOCKING THE CODE Bryant McAllister, PhD SNP Matching rsid chromosome posion Grandchild GP1 GP2 rs2340592 1 910935 GG GG GG rs13303118 1 918384 GG TT TG In this database, each such piece is numbered, and is known as a “Single Nucleotide Polymorphism” or SNP for short (it’s pronounced “snip”). Phenotype – a name or descriptor for the trait (phenotype) of interest. where is RsMergeArch. RSID - SNP ID in dbSNP 142; SNP. Querying NCBI dbSNP for rsID mergers with Python (a. Using the remainder of Reference SNP identification definition, categories, type and other relevant information provided by All Acronyms. We’ve chosen to focus on rs1121980 alone as this SNP was found to demonstrate the strongest effect 4 . The format of the output file is the same as that specified for the parameter --out , except it will only have two lines: the first line will be headers and the second line will be the corresponding values for the PHEWAS against the specified SNP. I would prefer using R to Y-DNA Haplogroup Tree 2018 Y-DNA SNP Index on Spreadsheet - 2018. Enter SNP rsid or chr:pos(hg19). snp. The fields are position, base change, rsID, SNP name, reliability and a list of the reference genomes which share this change. Watch Sandbox demo video No. Version 2. Additionally, the GDS (or NetCDF) les and SNP and scan annotation can be linked through the GenotypeData and IntensityData classes, which have slots for a GenotypeReader (or Inten- sityReader) object, a SnpAnnotationDataFrame object, and a ScanAnnotationDataFrame object. rs66823261) to IGV to then be able to jump to the location of each of them when copy+pasting the rsID on the locus text box? Welcome to the Mutalyzer website. Each SNP Data items should be in order: RSID, Chromosome Number, SNP Position Number, a single string with both alleles A space-separated file with no quotes on any data. Columns two and three contain the chromosome and basepair position of the SNP using human reference build 37. 10. You can qeury our data in two ways: by providing a (i) SNP rsID, or a (ii) gene symbol. Open your Livewello SNP Sandbox App. SNP Rich and SNP Poor areas are due to the number and location [] If two DNA segments look about the same length, why aren’t they the same number of centiMorgans? The recombination rate across the human autosomal genome is highly variable. The rs ID Hi I am working on SNPs genotyping and I have made literature search and some non-redundant Reference SNP cluster, which is assigned a unique rsid. SNP Single nucleotide polymorphisms, frequently called SNPs (pronounced 'snips'), are the most common type of genetic variation among people. MyHeritage DNA reports data for the SNPs located on the forward strand as regards to the human reference genome. The rsID annotation tells you there is a known snp at that position. After doing some investigating, the dbSNP build would actually be 126. There is a critical mass of published research related to the SNP. Download your raw data from 23andMe (or use one of the files from me or my colleagues at Genomes Unzipped); Mouse over the rsID and your own genotype for that SNP will appear. HCB: The MAF information of Han Chinese from 23-2-2015 · This video is part of an online course, Tales from the Genome. FUSION is a suite of tools for performing a transcriptome-wide (or any other ome-wide) association study by predicting functional/molecular phenotypes into GWAS using only summary statistics. in this case, the labels remain the same, but whether the minor allele is A or T will still depend on strand). Raw genome data Fields are TAB-separated. The Single Nucleotide Polymorphism Database (dbSNP) is a free public archive for genetic variation within and across different species developed and hosted by the National Center for Biotechnology Information (NCBI) in collaboration with the National Human Genome Research Institute (NHGRI). Each row represents a SNP site. dbSNP. Louis I am new to bioinformatics, and I have some new SNP data from an Affymetrix Axiom array. Reference SNP identification definition, categories, type and other relevant information provided by All Acronyms. Please come back again later. 0 (+-0. There are four successive sections: shared SNPs, private SNPs, shared INDELs and pricate INDELs. Eupedia Home > Genetics > Genes & SNP's > Cancer-related mutations Genes and mutations associated with cancers If you tested your DNA with a personal genomics service like 23andMe , DeCODEme , FTDNA 's Family Finder or another testing company, you can learn more about your risk factors for hundreds of diseases. RSID stands for Reference SNP identification The Single Nucleotide Polymorphism database (dbSNP) is a public-domain archive for a broad collection of simple genetic polymorphisms. txt file). In this example the rs numbers (rsid) are the name of the SNP, the position where it is located on the chromosome and the genotype ("AA") is the reported value for that SNP. Check out the course here: https://www. North Deerfield, IL, USA Single Nucleotide Polymorphisms in the Human Genome- SNP Database Pui-Yan Kwok Washington Univ. I Have the Results of My Genetic Genealogy Test, Now What? by Blaine T. St. I have the genotypes exported into a giant tab-delimited table txt file where each row is a sample, starting with the rsID and each column being a sample. stackexchange. This Y-DNA SNP testing chart provides comparative information on the Y chromosome SNP tests offered by the major DNA testing companies. I would like to know whether I can use Galaxy or some other source to identify the rsID for the SNP based on chromosome and BP position (build 37). Posts about SNP (Single Nucleotide Polymorphism) written by Roberta EstesList of cancers with the associated genes and alleles. Once one has identified potential variants, it is common to annotate them in relation to the genes these variants sit in or genes in the proximal region. Mutalyzer will retrieve the HGVS description of the SNP specified on the reference sequence(s) used by dbSNP. Known SNP: Known SNP description as reported in the tool's genome-wide score Region Score, TSS Score, Unmatched Score : prediction scores from 3 different versions of the classifier, which are all in the range [0-1] with higher scores indicating variants predicted as more likely to be functional. 20120608, but is found in dbSNP 137? I am having this problem with SNP rs7775397. The ‘other’ contains the SNP identifiers The SNP analyzer is a way to aggregate information, often from contradicting SNPs. SNP Query Column one provides the SNP identifier (rsID where possible). wikipedia. Eventually, all should be feeding into the NIH RSid master database. Isolating useful information from this was tricky. GWAs or eQTL studies attempt to find the variants, typically SNP or indel, that are associated with the disease or gene expression changes. Notice: If the user uploads more than 10000 SNP RSid, the computing speed will become slow. Central Mutation & SNP Databases Database Curator ; dbSNP-polymorphism repository: NCBI, NIH, Bethesda The SNP Consortium, Ltd. SNP – the SNP rsID from dbSNP. Y-STR haplotype tools (modals, genetic distance, TMRCA) The following is a selection of tools that can be used for a set of Y-STR values (DYS etc. - miRNA: a human microRNA. You can find index SNP file, 3 bed files, SNP Converter. , rs ID), and physical positions based on hg19 should be specified. Hello, I tried the same scneraio by adding a single SNP item to the SNP data list and I was not able to reproduce the issue. Data items should be in order: RSID, Chromosome Number, SNP Position Number, a single string with both alleles A tab-separated file with an initial line beginning with # and containing the string "AncestryDNA", and no quotes on any data. Is it possible to load a list of rsID identifiers (e. index. Gene rsID Minor Allele Genotype Phenotype 1 CETP rs1800775 C AC +/- 4 MUC21 rs1634731 G AA -/-5 TBC1D27 rs3751987 A __ NC 6 TNFRSF13B rs4792800 G __ NC METHYLATIONGene rsID Minor Allele Genotype Phenotype 1 CETP rs1800775 C AC +/- 4 MUC21 rs1634731 G AA -/-5 TBC1D27 rs3751987 A __ NC 6 TNFRSF13B rs4792800 G __ NC METHYLATIONY-DNA haplogroup converter A useful tool which allows you to enter your most downstream SNP name and see the haplogroup an index of markers and their RSID The description expands to show downloads available for heritability report (. p13 (chromosome) SNP. 3-11-2013 · First Look at the Full Genomes Y-Sequencing Results from Itaï Perez (**Warning The fields are position, base change, rsID, SNP name, SNP Converter. Name Generator. Simple Nucleotide Polymorphisms (dbSNP 142) Found in >= 1% of Samples The reference allele here is a T, and C is the affected polymorphism for this SNP. columns containing variables such as (for SNPs) snpID, chromosome, position, rsID, A and B alleles and (for scans) scanID, subject ID (to link duplicate scans of the same subject), sex, and phenotype. Top Definition: Residential System IdentifierUKBB GWAS Manifest 20170915 Share. openSNP allows customers of direct-to-customer genetic tests to publish their test results, find others with similar genetic variations, learn more about their results by getting the latest primary literature on their variations, and help scientists find new associations. Please see an example below. To use this resource, please type in a gene symbol, or rsid to find a gene or variant of interest and click Search. Affymetrix is dedicated to developing state-of-the-art technology for acquiring, analyzing, and managing complex genetic information for use in biomedical research. Scientists and medical professionals use the rsID as a standard for identifying SNPs in a person’s genome This number is very important, as other information describing SNPs, for example its position, may change over time. Please insert a dbSNP rs number below. I explain that an STR or Short Tandem Repeat is a different kind of a Query and visualize ChIA-PET and PLAC-Seq data, by simply typing in a gene name, SNP ID, or a genomic locus. snpInfo A data. A single SNP on chromosomes 1-22 ,in most cases may just suggest an ancestral population like Irish over Italian, if you do not have a segment of multiple identical SNP's you will not be in close relationship. SNP's are the DNA genetic markers that are tested for in Genetic Genealogy. I have several SNP IDs (i. Possible values: Y(yes), N(no) Associated SNPs: SNPs associated with the disease as reported 10 meanings of RSID acronym and RSID abbreviation. Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. Input format. Column one provides the SNP identifier (rsID where possible). This alternate ID should be used to access the chip information from the corresponding company. The more common rs429358 allele is (T). Alzheimer’s and APOE type Published by Debbie Moon on March 18, 2015 One very important gene that has been researched in association with Alzheimer’s disease is the APOE gene, which is involved in carrying cholesterol and other fats in your bloodstream. The SNP is found in a gene that belongs to a biochemical pathway that is covered by StrateGene. The DGN imputed genotype files were filtered so that only SNPs that were part of hapmap were included (matched by chromosome/position), and those hapmap snps are part of dbsnp 126. It is important to know on which strand your data is located. 23andMe To YSNPs If you have a 23andMe raw data file which contains Y-DNA data with refSNPs/RSID but not the names of Y-SNPs in ISOGG format, this tool will help you. For example, a SNP may replace the nucleotide cytosine (C) with the The rs number is an accession number used by researchers and databases to refer to specific SNPs. The Short Genetic Variations database (dbSNP) is a public-domain archive for a broad collection of comman and rare small germline and somatic sequence variations. The HRS data consists of SNPs with all three types of names. Like most genes, variations in the BRCA1 gene can be either causal for a given disease, or associated with somewhat higher The authors would like to thank the NHLBI GO Exome Sequencing Project and All data were simultaneously analyzed for exome SNP When querying a rsID, Querying NCBI dbSNP for rsID mergers with Python (a. The rsid numbers for SNPs in Health and Traits reports Sep 10, 2018 dbSNP entrez will transition to a new single compact eSummary format. Some very leading edge as part of NGS test analysis. The resulting many-megabyte file is full of rsid data and the actual allele sequences. A Single Nucleotide Polymorphism, or SNP, is a small genetic change, or variation, that can occur within a person's DNA sequence. Displays the fundamental description of an SNP sensing Probe Set. The SNP_A### identifiers are very likely Affymetrix SNP ids. 4. bcp. D. 010000). csv”. the data is stored in a single table indexed by SNP id (rsid) and Pubmed citation id (PMID), there are a num- an integrated evolutionary and GRASP resource for The bim file contains the SNP names and map positions. so, for example, a A/C SNP will become a T/G; alternatively, a A/T SNP will become a T/A SNP (i. Count of Markers by Type and Chromosome. I often get questions that a specific variant was not assigned a dbSNP rs identifier by ANNOVAR, even though it is supposed to be a "known" SNP. CHROMOSOME – Provides the name of the autosomal file, that is 1 This video is part of an online course, Tales from the Genome. lst --update-name --make SNP identifier Old allele code for one allele Old allele code for other allele Luckily, 1926013 of my 1936864 SNPs (99. The rsID for the mutation is rs3827760 and its SNPedia page is here. Release Version: v. Introduction Genome Graphs is a tool for displaying genome-wide data sets such as the results of genome-wide SNP association studies, linkage studies and homozygosity mapping. bcp. (3 replies) Hi, Has anyone ever had a case where a SNP was not found in SNPlocs. 8 Jun 2018 This SNP, located in the fourth exon of the ApoE gene, affects the amino acid at position 130 of the resulting protein. Summary. In the chart, each SNP’s rsid number is followed by the version of the SNP that is less prevalent in the population. Restriction fragment length polymorphism (RFLP) enzyme information for SNP genotype is available to all SNP IDs and tag SNPs. Publications on this SNP on the Public Library of Science: There are no PLoS-results yet. - SNP: a SNP rsid - limit: maximum number of records to show - Search type: selects for Identification of SNP and gene map positions from an updated reference genome > dim(snpMapAnn$rsid_map) [1] 306252 3 > dim(snpMapAnn38$rsid_map)Is it possible to load a list of rsID identifiers (e. Holden, The SNP Consortium, Ltd. zip, to put less strain on SNPedia in case of multiple runs. It then computes a score, based on the sum of log odds ratios for each risk allele for each SNP in a genetic profile, as well as a frequency based on multiplying the allele frequencies, assuming Hardy Weinberg equilibrium. SNP Converter. , rs16828074, rs17232800, etc), I want to their coordinates in a Hg19 genome from UCSC genome website. GetGeneandSNPInformation Inpractice,comprehensivelistsofgenesandSNPscanbedownloaded fromtheHUGOGeneNomenclatureCommittee[3],anddbSNP[5], respectively. rs66823261) to IGV to then be able to jump to the location of each of them when copy+pasting the rsID on the The NHGRI-EBI GWAS Catalog: a curated collection of all published genome-wide association studies, produced by a collaboration between EMBL-EBI and NHGRIData formats in GWASTools SNP information, and sample information) in a single S4 object, > rsID <- getVariable(gds, "snp. If there is an "alternate-id" attached to a chip in the GenotypingChipIDs column, it is an ID representing the same SNP as the rs ID listed in the "rsID" column. Each table includes ten columns: the marker names in build hg18 and hg19, the marker names in rsid format, the two alleles of the SNP, the effect size associated with the SNP, the corresponding standard error, the number of individuals evaluated for the SNP, the combined p-value for the SNP and the frequency of the first allele (the trait GetGeneandSNPInformation Inpractice,comprehensivelistsofgenesandSNPscanbedownloaded fromtheHUGOGeneNomenclatureCommittee[3],anddbSNP[5], respectively. SNPinfo is designed to comprehensively utilize computational (function prediction of SNP allele), experimental and epidemiological information together with recent genome wide association (GWAS) results and linkage disequilibrium (LD) information to prioritize SNPs for further genetic mapping studies rsID Gene Variant PEP Your Genotype Genotype Freq Category Publication Highlights rs650108 MMP-3 N/A G N/A N/A tendon strength Degrades collagens and other proteins rs650108 SNP of MMP-3 were associated with increased risk of post-operative stiffness susceptibility and severity. com/genes/slc2a14The risk allele ‘G’ of the SNP rs10846086 in the SLC2A14 gene has been associated with an increased risk of developing ulcerative colitis and rsID Number SNPs that cannot be converted from rsID to chr: There is an example directory in ~/GREGOR. rsid snpThe Single Nucleotide Polymorphism Database (dbSNP) is a free public archive for genetic To accommodate this, dbSNP routinely assembles identical submitted SNP records into a single reference SNP record, which is also a unique and Genome-wide association studies linking SNPs to traits or conditions usually report their results by rsid. Others part of the slower, more formal Input: - Gene: either a gene name or a refGene id. . A Single nucleotide polymorphism or SNP (pronounced snip) is a DNA sequence variation occurring when a single nucleotide - A, T, C, or G - in the genome (or other shared sequence) differs between members of a species (or between paired chromosomes in an individual). 20120608 package Bioconductor xCentral Mutation & SNP Databases Database Curator ; dbSNP-polymorphism repository: NCBI, NIH, Bethesda The SNP Consortium, Ltd. SNP_DISTANCE : Distance of SNP(s) from query base of the probe. Top Definition: Residential System Identifier SNP (single nucleotide polymorphism) testing is a different type of testing that tests single locations for mutations in order to confirm and further refine Each rsid identifies a unique SNP in the genome. ) including calculating the time to the most recent common ancestor. 1st column: SNP rsID (must be the same rsID as in the MAP file) Welcome to the Mutalyzer website. Generally, what people really want to understand is the difference between the products, and a basic answer is really all they want. August 10, 2008 By massie under Health and Traits, The SNP is in the COMT gene, If you have a 23andMe raw data file which contains Y-DNA data with refSNPs/RSID but not the names of Y-SNPs in ISOGG format, this tool will help you. udacity. Email The SNP Consortium is a nonprofit organization that sequences and records single nucleotide polymorphism records in a public domain bigsnpr {bignspr} is an R package for the analysis of massive SNP arrays. frame object of SNP location info with columns ’chr’,’pos’, and ’rsid’, or a tab-delimited file with those columns and one record per row. 16-1-2013 · Question: Problem locating SNP by rsID for SNPlocs. Chromosome number, SNP names (i. 0. 613689, and has been supported by grants 2007-35616-17882 and 2010-65205-20407 from the USDA National Institute of Food and Agriculture. Offers a platform dedicated to the investigation of single nucleotides polymorphisms (SNP) and indels involved into transcription factor binding (TFB) within the human genome. For information on the Y-STR tests used for genealogical DNA matching purposes within surname DNA projects see the Y-DNA STR testing chart. This SNP, located in the fourth exon of the ApoE gene, affects the amino acid at position 130 of the resulting protein. The client-side functionality employs jQuery, Bootstrap, D3. Please contact snp-admin@ncbi. Use the pull-down menu by your name to select 'browse raw data' and the box on the right says SNP - paste it there. The rsID (Reference SNP cluster ID) is a number used by scientists to identify specific SNPs in the genome. info: Query and visualize Capture Hi-C data, by simply typing in a gene name, SNP ID, or a genomic locus. I tested Y-DNA67 markers and the specific SNP for R-M512 at FamilytreeDna with the result being Confirmed Haplogroup of R-M512. The tests implemented include The SNP RSID_10 is coded as an additive Family Finder single SNP's should be looked at a little differently then YDNA due to the recombination of parents maternal and paternal chromosomes when they are passed onto children generation to generation. e. User questions and answers on Genome Graphs and other topics are available in the Genome Browser mailing list. Reads 23andMe-genome-file, downloads the SNP information from that file from SNPedia and saves it in the zip file snpedia-archive. For each SNP, we provide its identifier (an # rsid or an I want to check my bloodtype based on my SNPs data. I am aware that each company may use a different testing method (SNP vs STR) to arrive at the result. SNP rsID Minor Allele Each SNP represents a difference in a single DNA building block, called a nucleotide. 4%) were known rsIDs, so it does not appear to be a problem with the age of the SNP db we are using. In your case you have a different alternate allele. 0 8 designation using STR results rather than SNP results is a matter of statistical probability rather than The first row includes rsID, snp_position, and individual names, as used in the pedigree file. js and jsf-local-aerial. Reports in this format are produced by both PolyPhen-2 Batch query web service, as well as by standalone PolyPhen-2 software. I cross-referenced some of the rsids used for common traits from 23andMe with the SNP database . gz?)How can I find the SNPs rs number ?? they are merged into the same, non-redundant Reference SNP cluster, which is assigned a unique rsid. Allows you to convert a dbSNP rsId to HGVS notation. Promethease is a literature retrieval system that builds a personal DNA report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia. This is something that you can do with the Ensembl REST API with the following POST request: Users can annotate a single SNP, insertion/deletion (InDel) or block substitution by selecting one of the input formats and supplying the required data into the Reference SNP cluster 'rs' ID's are created by NCBI during periodic 'builds' of the I think dbSNP developers themselves are confused what is rsID: the rsID Genome-wide association studies linking SNPs to traits or conditions usually report their results by rsid. SnpTracker is a Java-based tool developed to extract the latest version rsID and genomic coordinates of SNPs given any version of rs ID(s) according to the SNP track history RsMergeArch (Version: b142;hg19/hg38) , coordinates data SNPChrPosOnRef (hg19/hg38) and deleted history SNPHistory(hg19/hg38) in dbSNP. For an autosomal file, that is 1 through 22. Arthur L. Effect Allele – the specific allele {A, T, C, or G} that influences the expression of the trait of interest. rsID log 10 (p)Gene(s)nearby reference SNP identifier (rsID) are used to identify every single SNP entry in the Single Nucleotide Polymorphism Database (dbSNP), which is the largest database maintained by the While using SNP Sandbox, I got a message that says “23andme does not recognize the rsid” The reason 23andMe does not recognize the rsID is because Livewello SNP Sandbox searches dbSNP for every single SNP in the medical literature, that matches your search term. 87160618G>T Ser893Thr rs2032582 Association 2 RSID – Provides the Reference SNP cluster (RS) number for the SNP in the NIH dbSNP database. Column one provides the SNP identifier (rsID where #possible). Save SNPs ¶ The data displayed in the Genome Browser are stored in a MySQL database. Currently have 136 STR marker labels on Chromosome Y; Currently have 364,811 SNP marker labels on Chromosome Y Count of Markers by Type and Chromosome. Large-scale testing for SNP-motif interactions. Expression quantitative trait loci (eQTLs) analysis is commonly used to identify genetic variants affecting gene regulation. Before reading into this package’s special format, quality control and conversion can be done using PLINK, which can be called directly from R using snp_plinkQC and snp_plinkIBDQC. It’s designed with simplicity and performance emphasized. For example, an SNP genotype that is A A on the ‘forward strand’, will be T T on the ‘reverse strand’. The server-side uses DreamFactory and SQLite3 to store the coordinates (chromosome and position in GRCh37/hg19 and GRCh38/hg38) for each SNP rsID in dbSNP141. Hsapiens. An rsID is a reference SNP cluster ID: a unique number linked to a specific SNP. MyVariant. Purchase app to view your report To get your results for 19 SNPs in this gene template, click the Purchase app button above SNP rsID Minor AlleleHow common is it to see a "novel" SNP mutation in general? How do I determine blood-type from SNPs? rsid chromosome position allele1 allele2. Contents 1. 0 is a single microarray featuring all single nucleotide polymorphisms (SNPs) from the original two-chip Mapping 500K Array Set, as well as 420,000 additional non-polymorphic probes that can measure other genetic differences, such as copy number variation. POSITION - SNP location in GRCh37 SNP reported: Whether the known SNP is directly reported in the study. Did you put i3003626 in the SNP search? Use the pull-down menu by your name to select 'browse raw data' and the box on the right says SNP - paste it there. info:One common task that many users need to use ANNOVAR for is to assign dbSNP identifiers to SNP. SNPs that cannot be converted from rsID to chr:pos format are listed in the output file rsid. The SNP Array 5. Right below the search box, you will see a link that says "Find rsIDs by gene name" When you click on the “Find rsIDs by Gene Name link”, a pop box appears. Below are the frequencies from ALFRED with the populations in decreasing order of the frequency of the mutant Mongoloid C allele. This usually happens of dbSNP identifiers, and they assign rsid 26-6-2014 · #corresponds to a SNP. From my 5 raw data files, RSID SNP: 1: 100465652: 100000096: rs1464917391: A: G: NIH DBSNP VCF b151 GRCh38p7: Position hg18: 100238240: RSID SNP: 1 10-8-2008 · SNPwatch: Genetic Variant May Increase Risk for Anxiety Disorders. Is there a website I can go to to import SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. Problem locating SNP by rsID for SNPlocs. where SNP refers to the central associated SNP (give the rsID), CHR refers to the chromosome it's on, and FILE is the name of the file containing the association data (like DGI_chr9_hit. Genotype of added SNP (discrepant with genotype) A large number of discrepant genotypes could indicate that the files contain SNPs for different individuals. The dbSNP page from UCSC for rs1815739 lists the C allele as having a frequency of 59. livewello Gene Variance report Annabel 6 / F ALLERGY Gene rsID Minor Allele Genotype Phenotype 1 HLA rs2155219 G GG +/+ 2 HLA rs7775228 C CT +/-A gene variance report is a graphical representation of your genetic raw data, displayed as a color coded chart. org/wiki/DbSNPThe dbSNP can be searched using the Entrez SNP search tool. ” if not found in dbSNP) CHR = Chromosome BP = Base-pair position (hg19/b37) DATA FROM THE CONSORTIA WE ARE PART OF: DESCRIPTION. It enhances the features of package {bigstatsr} "rs4970420") snp_gene (rsid) Gene: RefGene name; miRNA: Mature miRNA name from mirBASE; Snp: SNP RSid; mirSVR: The mirSVR score of this binding site. I compared mine to a person who is not related to me in any way and about 42% of the genotypes match. gov if you have any comments A reference SNP ID number, or “rs” ID, is an identification tag assigned by NCBI to a group (or cluster) of SNPs that map to an identical location. The Bovine Genome Database is supported by the European Union's Seventh Framework Programme for research, technological development and demonstration under grant UnifiedGenotyper rsId vs dbSNP rsID. The idea for this project came to Bastian after he was genotyped by 23andMe in May 2011 and started playing around with his data. The first table is for Y chromosome only databases since that represents the majority. Passionate about something niche? ALLERGY Gene rsID Minor Allele Genotype Phenotype 1 HLA rs2155219 G GT +/-2 HLA rs7775228 C TT -/-CLOTTING FACTORS Gene rsID Minor Allele Genotype Phenotype Bioinformatics Stack Exchange is a question and answer site for researchers, developers, students, teachers, and end users interested in bioinformatics. The SNP rs234706 or C699T in the CBS gene is perhaps the most widely investigated CBS SNP, and also the most controversial. Ensembl UCSC CCDS. , rs16828074, rs17232800, etc), I want to their coordinates in a Hg19 genome from UCSC genome website. The variant is the SNP, the piece of the gene where the mutation in question is. I have several SNP IDs (i. CHROMOSOME – Provides the name of the autosomal file, that is 1 --rsid <rsid> If this parameter is provided, then a PHEWAS is performed on the SNP named . openSNP is a non-profit, open-source project that is about sharing genetic and phenotypic information. "By SNP" visualise the top ten most affected genes by SNP and relative p-values. Interestingly there are several SNPs in the FTO gene which associate together, which are sometimes all grouped together under the SNP ID rs9930506 5. A network-based approach to eQTL interpretation and SNP functional characterization. The rsid numbers for SNPs in Health and Traits reports 10 Sep 2018 dbSNP entrez will transition to a new single compact eSummary format. The entire work is identified by the Version Number and date given on the Main Page